Out of control: accelerated aging in uremia

Out of control: accelerated aging in uremia.

Next to a high morbidity, patients with end-stage renal failure (ESRD) suffer from a complex spectrum of clinical manifestations. Both the phenotype of patients with ESRD as well as the pathophysiology of uremia show interesting parallels with the general aging process. Phenotypically, patients with ESRD have an increased susceptibility for both cardiovascular as well as infectious disease and ...

Accelerated retinal aging in PACAP knock-out mice

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophic and neuroprotective peptide. PACAP and its receptors are widely distributed in the retina. A number of reports provided evidence that PACAP is neuroprotective in retinal degenerations. The current study compared retina cell type-specific differences in young (3-4months) and aged adults (14-16months), of wild-type (WT) ...

Accelerated Heat Aging Study of Phenolic/Basalt Fiber Reinforced Composites

One of the greatest impediments to use polymer-matrix composites is their susceptibility to degradation when exposed to the elevated temperatures and the limited knowledge on the thermal and mechanical properties of these composites at such temperatures. The objective of this study is to evaluate the effects of accelerated heat aging on the tensile properties of the Woven Basalt/Phenolic (WBP) ...

Humidity Control for the Accelerated Aging of Rocket Propellants

Sensitive materials, such as rocket propellants, can be placed in harsh environments of increased temperature and relative humidity (RH) to study the effects of environmental conditions over time in accelerated aging studies. Programmable ovens are common to research laboratories and can be used to regulate the temperature of the aging environment for long durations. Some commercial units inclu...

The control of phosphate excretion in uremia.